Scientists claim that obesity is closely associated with depression. Often, overweight entails emotional disorders and depression. Effexor antidepressant is a drug used to treat panic disorders, depression and social phobia.
It is believed that active substance Venlafaxine affects unbalanced chemicals in the brain that cause anxiety state or depression in humans.
Phentermine is a drug from the group of amphetamines used to treat obesity.
- By affecting the brain centers, Phentermine suppresses appetite and promotes rapid saturation.
During the treatment of depression with Effexor antidepressant, a slight weight loss was observed in about 5% of patients (up to 6% of the patient’s initial weight). Experts claim that Effexor contributes to the changing in the patient’s weight. However, cases of weight loss using Effexor are rare.
It should be noted that safety and effectiveness of Effexor antidepressant combined with Phentermine anorectic have not been studied. For this reason, experts do not recommend the simultaneous use of Phentermine amphetamine-like drug with Effexor antidepressant.
Moreover, Effexor should not be used as a drug for the obesity treatment and it is not recommended to combine it with other drugs for weight loss.
According to some reports, it was found that signs of increased sensitivity to sympathomimetics might occur in patients using Effexor. In addition, some sympathomimetic drugs (e.g., drugs from amphetamine group) may have serotonergic activity.
Therefore, doctors do not recommend the simultaneous use of Effexor selective serotonin reuptake inhibitor with Phentermine drug from amphetamine group. Simultaneous use may increase the risk of serotonin syndrome.
Serotonin syndrome is a rare and herewith a life-threatening reaction of the body to the use of drugs that increase serotonergic transmission.
The clinical signs of serotonin syndrome include three different types:
- Neuromuscular disorders – tremor, hyperreflexia, shock-like contraction of a muscle (myoclonus) and ataxia.
- Mental disorders – hallucinations, irritability, mental confusion and coma.
- Vegetative disturbances – excessive sweating, lability of blood pressure, tachycardia, hyperthermia.
In general, Phentermine appetite suppressant should not be combined with serotonin-norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs).